Coagulation system deficiency of enzyme necessary for blood clotting.BloodEncyclopedia Entry for Factor X Deficiency :Factor X deficiency. When you bleed, a series of reactions take place in the body that helps blood clots form. This process is called the coagulation cascade. It involves special proteins called coagulation, or clotting, factors. You may have a higher chance of excess bleeding if one or more of these factors are missing or are not functioning like they should. Factor X is one such coagulation factor. Factor X deficiency is often caused by an inherited defect in the factor X gene. This is called inherited factor X deficiency. Bleeding ranges from mild to severe depending on how severe the deficiency is. Factor X deficiency can also be due to another condition or use of certain medicines. This is called acquired factor X deficiency. Acquired factor X deficiency is common. It can be caused by: Lack of vitamin K (some newborns are born with vitamin K deficiency) Buildup of abnormal proteins in the tissues and organs ( amyloidosis ) Severe liver disease Use of medicines that prevent clotting (anticoagulants such as warfarin) Women with factor X deficiency may first be diagnosed when they have very heavy menstrual bleeding and bleeding after childbirth. The condition may be first noticed in newborn boys if they have bleeding that lasts longer than normal after circumcision.Symptoms may include any of the following: Bleeding into the joints Bleeding into the muscles Bruising easily Heavy menstrual bleeding Mucus membrane bleeding Nosebleeds that do not stop easily Umbilical cord bleeding after birth.Tests that may be done include: Low factor X activity Normal thrombin time Prolonged partial thromboplastin time (PTT) Prolonged prothrombin time (PT).Bleeding can be controlled by getting intravenous (IV) infusions of plasma or concentrates of clotting factors. If you lack vitamin K, your doctor will prescribe vitamin K for you to take by mouth, through injections under the skin, or through a vein (intravenously). If you have this bleeding disorder, be sure to: Tell your health care providers before you have any kind of procedure, including surgery and dental work. Tell your family members because they may have the same disorder but do not know it yet.Find out more about bleeding disorders through these groups: American Society of Hematology -- www.hematology.org/Patients/Blood-Disorders.aspx National Hemophilia Foundation: Other Factor Deficiencies -- www.hemophilia.org/Bleeding-Disorders/Types-of-Bleeding-Disorders/Other-Factor-Deficiencies National Hemophilia Foundation: Victory for Women with Blood Disorders -- www.hemophilia.org/Community-Resources/Women-with-Bleeding-Disorders/Victory-for-Women-with-Blood-Disorders.The outcome is good if the condition is mild or you get treatment. Inherited factor X deficiency is a lifelong condition. The outlook for acquired factor X deficiency depends on the cause. If it is caused by liver disease, the outcome depends on how well your liver disease can be treated. Taking vitamin K supplements will treat vitamin K deficiency. If the disorder is caused by amyloidosis, there are several treatment options. Your doctor can tell you more.Severe bleeding or sudden loss of blood (hemorrhage) can occur. The joints may get deformed in severe disease from many bleeds.Get emergency medical help if you have an unexplained or severe loss of blood.There is no known prevention for inherited factor X deficiency. When a lack of vitamin K is the cause, using vitamin K can help.Stuart-Prower deficiency.Blood clot formation Blood clot formation Blood clots Blood clots.Gailani D, Neff AT. Rare coagulation factor deficiencies.