Neurological disorder with loss of brain's ability to regulate sleep-wake cycles, leading to inappropriate sleep times/places, and daytime tiredness.Encyclopedia Entry for Narcolepsy :Narcolepsy. Experts aren't sure of the exact cause of narcolepsy. It may have more than one cause. Many people with narcolepsy have a low level of hypocretin (also known as orexin). This is a chemical made in the brain that helps you stay awake. In some people with narcolepsy, there are fewer of the cells that make this chemical. This may be due to an autoimmune reaction. An autoimmune reaction is when the body's immune system mistakenly attacks healthy tissue. Narcolepsy can run in families. Researchers have found certain genes linked to narcolepsy.Narcolepsy symptoms usually first occur between 15 and 30 years old. Below are the most common symptoms. EXTREME DAYTIME SLEEPINESS You may feel a strong urge to sleep, often followed by a period of sleep. You can't control when you fall asleep. This is called a sleep attack. These periods can last from a few seconds to a few minutes. They may happen after eating, while talking to someone, or during other situations. Most often, you wake up feeling refreshed. Attacks can occur while you are driving or doing other activities where falling asleep can be dangerous. CATAPLEXY During these attacks, you can't control your muscles and can't move. Strong emotions, such as laughter or anger, can trigger cataplexy. Attacks often last from 30 seconds to 2 minutes. You remain aware during the attack. During the attack, your head falls forward, your jaw drops, and your knees may buckle. In severe cases, you may fall and stay paralyzed for as long as several minutes. HALLUCINATIONS You see or hear things that aren't there, either as you fall asleep or when you wake up. During hallucinations , you may feel afraid or under attack. SLEEP PARALYSIS This is when you can't move your body as you start falling asleep or when you first wake up. It may last up to 15 minutes. Most people with narcolepsy have daytime sleepiness and cataplexy. Not everyone has all these symptoms. Surprisingly, despite being very tired, many people with narcolepsy don't sleep well at night. There are two main types of narcolepsy: Type 1 involves having excessive daytime sleepiness, cataplexy, and a low level of hypocretin. Type 2 involves having excessive daytime sleepiness, but no cataplexy, and a normal level of hypocretin.Your health care provider will do a physical exam and ask about your symptoms. You may have a blood test to rule out other conditions that can cause similar symptoms. These include: Insomnia and other sleep disorders Restless legs syndrome Seizures Sleep apnea Other medical, psychiatric, or nervous system diseases You may have other tests, including: ECG (measures the electrical activity of your heart) EEG (measures the electrical activity of your brain) Sleep study (polysomnogram) Multiple sleep latency test (MSLT). This is a test to see how long it takes you to fall asleep during a daytime nap. People with narcolepsy fall asleep much faster than people without the condition. Genetic testing to look for the narcolepsy gene.There is no cure for narcolepsy. However, treatment can help control symptoms. LIFESTYLE CHANGES Certain changes can help improve your sleep at night and ease daytime sleepiness: Go to bed and wake up at the same time every day. Keep your bedroom dark and at a comfortable temperature. Make sure your bed and pillows are comfortable. Avoid caffeine, alcohol, and heavy meals several hours before bedtime. Don't smoke. Do something relaxing, such as take a warm bath or read a book before going to sleep. Get regular exercise every day, which can help you sleep at night. Be sure you plan exercise several hours before bedtime. These tips can help you do better at work and in social situations. Plan naps during the day when you typically feel tired. This helps control daytime sleepiness and reduces the number of unplanned sleep attacks. Tell teachers, work supervisors, and friends about your condition. You may want to print out material from the web about narcolepsy for them to read. Get counseling, if needed, to help you cope with the condition. Having narcolepsy can be stressful. If you have narcolepsy, you may have driving restrictions. Restrictions vary from state to state. MEDICINES Stimulant medicines can help you stay awake during the day. Antidepressant medicines can help reduce episodes of cataplexy, sleep paralysis, and hallucinations. Sodium oxybate (Xyrem) works well to control cataplexy. It can also help control daytime sleepiness. These drugs may have side effects. Work with your provider to find the treatment plan that works for you.Narcolepsy is a lifelong condition. It may be dangerous if episodes occur while driving, operating machinery, or doing similar activities. Narcolepsy can usually be controlled with treatment. Treating other underlying sleep disorders can improve narcolepsy symptoms.Narcolepsy may lead to the following: Trouble functioning at work Trouble being in social situations Injuries and accidents if attacks occur during activities Side effects of medicines used to treat the disorder.Call your provider if: You have symptoms of narcolepsy Narcolepsy does not respond to treatment You develop new symptoms.You can't prevent narcolepsy. Treatment may reduce the number of attacks. Avoid situations that trigger the condition if you are prone to attacks of narcolepsy.Daytime sleep disorder; Cataplexy.Sleep patterns in the young and aged Sleep patterns in the young and aged.Chokroverty S, Avidan AY. Sleep and its disorders.