Chronic inflammation of the muscles (Inflammatory Myopathy) related to Dermatomyositis and inclusion body Myositis.Encyclopedia Entry for Polymyositis :Polymyositis - adult. Polymyositis affects the skeletal muscles. It is also known as idiopathic inflammatory myopathy. The exact cause is unknown, but it may be related to an autoimmune reaction or infection. Polymyositis can affect people at any age. It is most common in adults between ages 50 and 60, and in older children. It affects women twice as often as men. It is more common in African Americans than white people.Polymyositis is a systemic disease. This means it affects the whole body. Muscle weakness and tenderness can be signs of polymyositis. A rash is a sign of a similar condition, dermatomyositis. Common symptoms include: Muscle weakness in the shoulders and hips. This can make it hard to raise the arms over the head, get up from a sitting position, or climb stairs. Difficulty swallowing. Muscle pain. Problems with the voice (caused by weak throat muscles). Shortness of breath. You may also have: Fatigue Fever Joint pain Loss of appetite Morning stiffness Weight loss.Tests may include: Autoimmune antibodies and inflammation tests CPK Serum aldolase Electromyography MRI of affected muscles Muscle biopsy Myoglobin in the urine People with this condition also must be watched carefully for signs of cancer.The main treatment is the use of corticosteroid medicines. The dose of medicine is slowly tapered off as muscle strength improves. This takes about 4 to 6 weeks. You will stay on a low dose of a corticosteroid medicine after that. Medicines to suppress the immune system may be used to replace the corticosteroids. These drugs may include azathioprine, methotrexate or mycophenolate. For disease that remains active in spite of corticosteroids, intravenous gamma globulin has been tried with mixed results. Biologic drugs also may be used. Rituximab appears to be the most promising. It is important to rule out other conditions in people who do not respond to treatment. A repeat muscle biopsy may be needed to make this diagnosis. If the condition is associated with a tumor , it may improve if the tumor is removed.Response to treatment varies, based on the complications. As many as 1 in 5 people may die within 5 years of developing the condition. Many people, especially children, recover from the illness and do not need ongoing treatment. For most adults, however, immunosuppressant drugs are needed to control the disease. In adults, death may result from: Malnutrition Pneumonia Respiratory failure Severe, long-term muscle weakness The major causes of death are cancer and lung disease.Complications may include: Calcium deposits in the affected muscles, especially in children with the disease Cancer Heart disease, lung disease , or abdominal complications.Call your health care provider if you have symptoms of this disorder. Seek emergency treatment if you have shortness of breath and difficulty swallowing.Superficial anterior muscles Superficial anterior muscles.Amato AA. Disorders of skeletal muscle.