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Tardive Dyskinesia

Disorder with involuntary repetitive movements. Caused by antipsychotic drug use for longer than three months in adults, and GI drugs in children and infants.Encyclopedia Entry for Tardive Dyskinesia :Tardive dyskinesia. TD is a serious side effect that occurs when you take medicines called neuroleptics. These drugs are also called antipsychotics or major tranquilizers. They are used to treat mental problems. TD often occurs when you take the drug for many months or years. In some cases, it occurs after you take them for as little as 6 weeks. Medicines that most commonly cause this disorder are older antipsychotics, including: Chlorpromazine Fluphenazine Haloperidol Perphenazine Prochlorperazine Thioridazine Trifluoperazine Newer antipsychotics seem less likely to cause TD, but they are not entirely without risk. Other drugs that can cause TD include: Metoclopramide (treats stomach problem called gastroparesis ) Antidepressant drugs such as amitriptyline, fluoxetine, phenelzine, sertraline, trazodone Antiparkinson drugs such as levodopa Antiseizure drugs such as phenobarbital and phenytoin.Symptoms of TD include uncontrollable movements of the face and body such as: Facial grimacing (commonly involving lower facial muscles) Finger movement (piano playing movements) Rocking or thrusting of the pelvis (duck-like gait) Jaw swinging Repetitive chewing Rapid eye blinking Tongue thrusting Restlessness.When TD is diagnosed, the health care provider will either have you stop the medicine slowly or switch to another one. If TD is mild or moderate, various medicines may be tried. A dopamine-depleting medicine, tetrabenazine is most effective treatment for TD. Your provider can tell you more about these. If TD is very severe, a procedure called deep brain stimulation DBS may be tried. DBS uses a device called a neurostimulator to deliver electrical signals to the areas of the brain that control movement.If diagnosed early, TD may be reversed by stopping the medicine that caused the symptoms. Even if the medicine is stopped, the involuntary movements may become permanent, and in some cases, may become worse.TD; Tardive syndrome; Orofacial dyskinesia; Involuntary movement - tardive dyskinesia; Antipsychotic drugs - tardive dyskinesia; Neuroleptic drugs - tardive dyskinesia; Schizophrenia - tardive dyskinesia.Central nervous system Central nervous system and peripheral nervous system.Aronson JK. Neuroleptic drugs.