Also called Adrenomyeloneuropathy. Fatty acid oxidation disorder.Encyclopedia Entry for Adrenoleukodystrophy :Adrenoleukodystrophy. Adrenoleukodystrophy is usually passed down from parent to child as an X-linked genetic trait. It affects mostly males. Some women who are carriers can have milder forms of the disease. It affects about 1 in 20,000 people from all races. The condition results in the buildup of very-long-chain fatty acids in the nervous system, adrenal gland, and testes. This disrupts normal activity in these parts of the body. There are three major categories of disease: Childhood cerebral form -- appears in mid-childhood (at ages 4 to 8) Adrenomyelopathy -- occurs in men in their 20s or later in life Impaired adrenal gland function (called Addison disease or Addison-like phenotype) -- adrenal gland does not produce enough steroid hormones.Childhood cerebral type symptoms include: Changes in muscle tone, especially muscle spasms and uncontrolled movements Crossed eyes Handwriting that gets worse Difficulty at school Difficulty understanding what people are saying Hearing loss Hyperactivity Worsening nervous system damage, including coma, decreased fine motor control, and paralysis Seizures Swallowing difficulties Visual impairment or blindness Adrenomyelopathy symptoms include: Difficulty controlling urination Possible worsening muscle weakness or leg stiffness Problems with thinking speed and visual memory Adrenal gland failure (Addison type) symptoms include: Coma Decreased appetite Increased skin color Loss of weight and muscle mass (wasting) Muscle weakness Vomiting.Tests for this condition include: Blood levels of very long chain fatty acids and hormones that are produced by the adrenal gland Chromosome study to look for changes (mutations) in the ABCD1 gene MRI of the head Skin biopsy.Adrenal dysfunction may be treated with steroids (such as cortisol) if the adrenal gland is not producing enough hormones. A specific treatment for X-linked adrenoleukodystrophy is not available. A bone marrow transplant can cure a people of the condition. Supportive care and careful monitoring of impaired adrenal gland function may help in improving comfort and quality of life.The following resources can provide more information on adrenoleukodystrophy: National Organization for Rare Disease Disorders -- rarediseases.org/rare-diseases/adrenoleukodystrophy NIH/NLM Genetics Home Reference -- ghr.nlm.nih.gov/condition/x-linked-adrenoleukodystrophy.The childhood form of X-linked adrenoleukodystrophy is a progressive disease. It leads to a long-term coma (vegetative state) about 2 years after nervous system symptoms develop. The child can live in this condition for as long as 10 years until death occurs. The other forms of this disease are milder.These complications can occur: Adrenal crisis Vegetative state.Call your health care provider if: Your child develops symptoms of X-linked adrenoleukodystrophy Your child has X-linked adrenoleukodystrophy and is getting worse.Genetic counseling is recommended for couples with a family history of X-linked adrenoleukodystrophy. Mothers of affected sons have an 85% chance of being a carrier for this condition. Prenatal diagnosis of X-linked adrenoleukodystrophy is also available. It is done by testing cells from chorionic villus sampling or amniocentesis. These tests look for either a known genetic change in the family or for very long chain fatty acid levels.X-linked Adrenoleukodystrophy; Adrenomyeloneuropathy; Childhood cerebral adrenoleukodystrophy; ALD; Schilder-Addison Complex.Neonatal adrenoleukodystrophy Neonatal adrenoleukodystrophy.James WD, Berger TG, Elston DM. Errors in metabolism.