Progressive loss of muscle tissue and touch sensation.Encyclopedia Entry for Charcot-Marie-Tooth Disease :Charcot-Marie-Tooth disease. Charcot-Marie-Tooth is one of the most common nerve-related disorders passed down through families (inherited). Changes to at least 40 genes cause different forms of this disease. The disease leads to damage or destruction to the covering ( myelin sheath) around nerve fibers.Nerves that stimulate movement (called the motor nerves) are most severely affected. The nerves in the legs are affected first and most severely. Symptoms most often begin between mid-childhood and early adulthood. They may include: Foot deformity (very high arch to feet) Foot drop (inability to hold foot horizontal) Loss of lower leg muscle, which leads to skinny calves Numbness in the foot or leg 'Slapping' gait (feet hit the floor hard when walking) Weakness of the hips, legs, or feet Later, similar symptoms may appear in the arms and hands. These may include a claw-like hand.A physical exam may show: Difficulty lifting up the foot and making toe-out movements (foot drop) Lack of stretch reflexes in the legs Loss of muscle control and atrophy (shrinking of the muscles) in the foot or leg Thickened nerve bundles under the skin of the legs Nerve conduction tests are often done to identify different forms of the disorder. A nerve biopsy may confirm the diagnosis. Genetic testing is also available for most forms of the disease.There is no known cure. Orthopedic surgery or equipment (such as braces or orthopedic shoes) may make it easier to walk. Physical and occupational therapy may help maintain muscle strength and improve independent functioning.Charcot-Marie-Tooth disease slowly gets worse. Some parts of the body may become numb, and pain can range from mild to severe. Eventually the disease may cause disability.Complications may include: Progressive inability to walk Progressive weakness Injury to areas of the body that have decreased sensation.Call your health care provider if there is ongoing weakness or decreased sensation in the feet or legs.Genetic counseling and testing is advised if there is a strong family history of the disorder.Progressive neuropathic (peroneal) muscular atrophy; Hereditary peroneal nerve dysfunction; Neuropathy - peroneal (hereditary); Hereditary motor and sensory neuropathy.Central nervous system Central nervous system and peripheral nervous system.Katirji B. Disorders of the peripheral nerves.