Disease with abnormal inflammatory cells forming lumps, usually starting in lungs, skin, or lymph nodes, sometimes eyes, liver, heart, or brain. Any organ can be affected. Also see Cancer Lymphogranuloma, and Lymphogranuloma.Encyclopedia Entry for Sarcoidosis :Sarcoidosis. The exact cause of sarcoidosis is unknown. What is known is that when a person has the disease, tiny clumps of abnormal tissue (granulomas) form in certain organs of the body. Granulomas are clusters of immune cells. The disease can affect almost any organ. It most commonly affects the lungs. Doctors think that having certain genes makes it more likely for a person to develop sarcoidosis. Things that may trigger the disease include infections with bacteria or viruses. Contact with dust or chemicals may also be triggers. The disease is more common in African Americans and white people of Scandinavian heritage. More women than men have the disease. The disease often begins between ages 20 and 40. Sarcoidosis is rare in young children. A person with a close blood relative who has sarcoidosis is nearly 5 times as likely to develop the condition.There may be no symptoms. When symptoms do occur, they can involve almost any body part or organ system. Almost all people affected by sarcoidosis have lung or chest symptoms: Chest pain (most often behind the breast bone) Dry cough Shortness of breath Coughing up blood (rare, but serious) Symptoms of general discomfort may include: Fatigue Fever Joint ache or pain (arthralgia) Weight loss Skin symptoms may include: Hair loss Raised, red, firm skin sores ( erythema nodosum ), almost always on the front part of the lower legs Rash Scars that become raised or inflamed Nervous system symptoms may include: Headache Seizures Weakness on one side of the face Eye symptoms may include: Burning Discharge from the eye Dry eyes Itching Pain Vision loss Other symptoms of this disease may include: Dry mouth Fainting spells, if the heart is involved Nosebleed Swelling in the upper part of the abdomen Liver disease Swelling of the legs if heart and lungs are involved Abnormal heart rhythm if the heart is involved.The health care provider will perform a physical examination and ask about the symptoms. Different imaging tests may help diagnose sarcoidosis: Chest x-ray to see if the lungs are involved or lymph nodes are enlarged CT scan of the chest Lung gallium scan (rarely done now) Imaging tests of the brain and liver Echocardiogram or MRI of the heart To diagnose this condition, a biopsy is needed. Biopsy of the lung using bronchoscopy is usually done. Biopsies of other body tissues may also be done. The following lab tests may be done: Calcium levels ( urine , ionized , blood ) CBC Immunoelectrophoresis Liver function tests Quantitative immunoglobulins Phosphorus Angiotensin converting enzyme (ACE).Sarcoidosis symptoms will often get better without treatment. If the eyes, heart, nervous system, or lungs are affected, corticosteroids are usually prescribed. This medicine may need to be taken for 1 to 2 years. Medicines that suppress the immune system are sometimes also needed. In rare cases, people with very severe heart or lung damage (end-stage disease) may need an organ transplant.Many people with sarcoidosis are not seriously ill, and get better without treatment. Up to half of all people with the disease get better in 3 years without treatment. People whose lungs are affected may develop lung damage. Overall death rate from sarcoidosis is less than 5%. Causes of death include: Bleeding from the lung tissue Heart damage, leading to heart failure and abnormal heart rhythms Lung scarring (pulmonary fibrosis).Sarcoidosis may lead to these health problems: Fungal lung infections ( aspergillosis ) Glaucoma and blindness from uveitis (rare) Kidney stones from high calcium levels in blood or urine Osteoporosis and other complications of taking corticosteroids for long periods of time High blood pressure in the arteries of the lungs ( pulmonary hypertension ).Call your provider promptly if you have: Difficulty breathing Irregular heartbeat Vision changes Other symptoms of this disorder.Interstitial lung disease - adults - discharge.Sarcoid, stage I - chest X-ray Sarcoid, stage I - chest x-ray Sarcoid, stage II - chest X-ray Sarcoid, stage II - chest x-ray Sarcoid, stage IV - chest X-ray Sarcoid, stage IV - chest x-ray Sarcoid - close-up of the skin lesions Sarcoid - close-up of the skin lesions Erythema nodosum associated with sarcoidosis Erythema nodosum associated with sarcoidosis Sarcoidosis - close-up Sarcoidosis - close-up Sarcoidosis on the elbow Sarcoidosis on the elbow Sarcoidosis on the nose and forehead Sarcoidosis on the nose and forehead Respiratory system Respiratory system Erythema nodosum associated with sarcoidosis Erythema nodosum associated with sarcoidosis.Judson MA, Morgenthau AS, Baughman RP. Sarcoidosis.Encyclopedia Entry for Sarcoidosis :Sarcoidosis. Disease with abnormal inflammatory cells forming lumps (Granulomas - see set), usually starting in lungs, skin, or lymph nodes, sometimes eyes, liver, heart, or brain. Any organ can be affected. Also see Cancer Lymphogranuloma, and Lymphogranuloma. Can be caused bybacteria Helicobacter pylori, Chlamydia trachomatis, Propionibacterium acnes, Borrelia burgdorferi, Mycoplasmas, Mycobacterium Tuberculosis, Rickettsie or Herpes virus, Epstein-Barr virus (EBV), Retrovirus.Information from Marcello Allegretti.