Liver cancer is cancer that begins in the cells of your liver. Your liver is a football-sized organ that sits in the upper right portion of your abdomen, beneath your diaphragm and above your stomach.Several types of cancer can form in the liver. The most common type of liver cancer is hepatocellular carcinoma, which begins in the main type of liver cell (hepatocyte). Other types of liver cancer, such as intrahepatic cholangiocarcinoma and hepatoblastoma, are much less common.Cancer that spreads to the liver is more common than cancer that begins in the liver cells. Cancer that begins in another area of the body such as the colon, lung or breast and then spreads to the liver is called metastatic cancer rather than liver cancer. This type of cancer is named after the organ in which it began such as metastatic colon cancer to describe cancer that begins in the colon and spreads to the liver.Encyclopedia Entry for Cancer Liver :Cancer Liver. Can be caused by Hepatitis B virus, Hepatitis C virus, and by the helminth Schistosoma japonicum.Information from Marcello Allegretti.