Coagulation system protein deficiency leading to predisposition for hemorrhage.BloodEncyclopedia Entry for Factor V Deficiency :Factor V deficiency. Blood clotting is a complex process involving as many as 20 different proteins in blood plasma. These proteins are called blood coagulation factors. Factor V deficiency is caused by a lack of factor V. When certain blood clotting factors are low or missing, your blood does not clot properly. Factor V deficiency is rare. It may be caused by: A defective factor V gene passed down through families (inherited) An antibody that interferes with normal factor V function You can develop an antibody that interferes with factor V: After giving birth After being treated with a certain type of fibrin glue After surgery With autoimmune diseases and certain cancers Sometimes the cause is unknown. The disease is similar to hemophilia , except bleeding into joints is less common. In the inherited form of factor V deficiency, a family history of a bleeding disorder is a risk factor.Excessive bleeding with menstrual periods and after childbirth often occurs. Other symptoms can include: Bleeding into the skin Bleeding of the gums Excessive bruising Nosebleeds Prolonged or excessive loss of blood with surgery or trauma Umbilical stump bleeding.Tests to detect factor V deficiency include: Factor V assay Blood clotting tests, including partial thromboplastin time (PTT) and prothrombin time Bleeding time.You will be given fresh blood plasma or fresh frozen plasma infusions during a bleeding episode or after surgery. These treatments will correct the deficiency temporarily.The following resources can provide more information on factor V deficiency: National Hemophilia Foundation -- www.hemophilia.org/Bleeding-Disorders/Types-of-Bleeding-Disorders/Other-Factor-Deficiencies/Factor-V NIH/NLM Genetics Home Reference -- ghr.nlm.nih.gov/condition/factor-v-deficiency.The outlook is good with diagnosis and proper treatment.Severe bleeding (hemorrhage) could occur.Go to the emergency room or call the local emergency number (such as 911) if you have an unexplained or prolonged loss of blood.Parahemophilia; Owren disease; Bleeding disorder - factor V deficiency.Blood clot formation Blood clot formation Blood clots Blood clots.Gailani D, Wheeler AP, Neff AT. Rare coagulation factor deficiencies.